Updating the effects of fatty acids on skeletal muscle

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This article is from Lipids in Health and Disease, volume 11.

Fat-free mass (FFM) and percent body fat were measured by dual-energy x-ray absorptiometry (GE Lunar Corp., Madison, WI).Physiological elevation of plasma FFA for 48 h down-regulates multiple genes involved in mitochondrial biogenesis (16).Although prolonged 48-h lipid infusion has been shown to reduce mitochondrial gene expression, it is unclear whether short-term plasma FFA elevation induces mitochondrial dysfunction and inhibits mitochondrial gene expression.Skeletal muscle relies on mitochondrial oxidative phosphorylation for ATP production.Mitochondrial dysfunction has been reported in skeletal muscle in patients with T2DM and in normal glucose tolerant (NGT) offspring of T2DM parents (8–10).

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